Xilio Therapeutics Appoints Tomas Heyman to Board of Directors

WALTHAM, Mass., Sept. 15, 2022 (GLOBE NEWSWIRE) — Xilio Therapeutics, Inc. (Nasdaq: XLO), a biotechnology company developing tumor-selective immuno-oncology therapies for people living with cancer, today announced the appointment of Tomas J. Heyman to the company’s board of directors. Mr. Heyman is a biopharmaceutical veteran with nearly 40 years of leadership and management expertise in corporate strategy, business development and venture capital from his tenure with Johnson & Johnson (J&J). In addition, the company announced that John Maraganore, Ph.D., former founding CEO of Alnylam Pharmaceuticals, will serve as a strategic advisor to Xilio’s board of directors and its executive team.

“Tom brings extensive global leadership experience from his tenure at J&J and has a strong track record of driving value creation and business development. John is an industry pioneer who built Alnylam from an early research platform concept to a global therapeutics company with multiple novel medicines. The collective experience of Tom and John will be highly valuable as Xilio continues to advance its innovative scientific platform and promising pipeline of tumor-selective immunotherapy programs,” said Paul Clancy, chair of the board of directors of Xilio Therapeutics. “We are thrilled to welcome Tom to the Xilio board of directors and John as a strategic advisor to the company, and we look forward to working with each of them and benefiting from their extensive strategic knowledge and expertise.”

“Xilio is pioneering an innovative platform to develop tumor-selective immunotherapies that have the potential to achieve meaningful anti-tumor activity while minimizing serious, systemic effects,” said Mr. Heyman. “I look forward to partnering with Xilio’s high-caliber board and leadership team as it seeks to advance its pipeline of potentially transformative clinical and pre-clinical programs.”

“I have known Rene and the Xilio team for some time, and I have been impressed with their approach, which is intended to precisely deliver immunotherapies directly to the tumor microenvironment minimizing their systemic side effects and improving their potency,” said Dr. Maraganore. “I am excited to partner with the team as a strategic advisor to advance their novel platform and work to bring the next generation of immune-oncology therapies to patients.”

In addition, Xilio announced the appointment of Myles Clouston to the newly created position of vice president of investor relations, where he will lead the company’s investor relations strategy and engagement. Mr. Clouston brings more than 20 years of experience to this role, with a strong understanding of the life science sector from his time at MorphoSys and Mylan (now Viatris) and nearly a decade of global investor relations, corporate development, and capital markets experience from his roles at NASDAQ, J&J, and Thomson Financial Corporate Services.

Tomas J. Heyman
Mr. Tomas Heyman brings significant biopharmaceutical experience in corporate strategy, business development, venture capital, as well as R&D, legal and operational management experience. Mr. Heyman most recently served as president of JJDC, J&J’s corporate venture capital group, until September 2019, where he managed approximately $1.5 billion in capital and oversaw investments in more than 120 companies. Prior to leading JJDC, he led business development for J&J’s pharmaceutical group, Janssen, for over 20 years, completing hundreds of licensing and M&A transactions. He was also the managing director of Janssen Pharmaceutica, Belgium, J&J’s largest subsidiary outside the U.S., and vice president of licensing at Ortho Pharmaceutical, a J&J affiliate. Mr. Heyman currently serves as a member of the boards of directors of Legend Biotech, Akero Therapeutics, OptiNose, and Adagio Therapeutics. Mr. Heyman received his Master of Law from K.U. Leuven in Belgium and completed post-graduate studies in international law in Geneva, Switzerland, and post-graduate studies in business management at the University of Antwerp in Belgium.

John M. Maraganore, Ph.D.
Dr. John Maraganore served as the founding chief executive officer and a director of Alnylam Pharmaceuticals from 2002 to 2021 and is a member of the Alnylam Scientific Advisory Board. During his tenure, he built and led the company from early platform research on RNA interference through global approval and commercialization of the first four RNAi therapeutics medicines, ONPATTRO®, GIVLAARI®, OXLUMO®, and Leqvio®. He also led Alnylam’s value creation strategy, building $25B in market capitalization and forming over 20 major pharmaceutical alliances. Previously, Dr. Maraganore held leadership and scientific roles at Millennium Pharmaceuticals, Biogen, Zymogenetics, and The Upjohn Company. He is currently a venture partner at ARCH Venture Partners, a venture advisor at Atlas Ventures, an executive partner at RTW Investments, and senior advisor for Blackstone Life Sciences. He is chair of the board of directors of Hemab Therapeutics and the chairman and co-founder of Orbital Therapeutics. Dr. Maraganore also serves as a member of the board of directors of Agios Pharmaceuticals, Beam Therapeutics, Kymera Therapeutics, ProKidney, and the Biotechnology Industry Organization, where he was chair from 2017-2019 and serves as chair emeritus. In addition, he serves on the board of the Termeer Foundation, chair of the n-Lorem Foundation Advisory Council, and on the advisory board of Ariadne Labs. Dr. Maraganore received his M.S. and Ph.D. in biochemistry and molecular biology at the University of Chicago.

About Xilio Therapeutics
Xilio Therapeutics is a clinical-stage biotechnology company focused on harnessing the immune system to achieve deep and durable clinical responses to improve the lives of patients with cancer. The company is using its proprietary geographically precise solutions (GPS) platform to rapidly engineer novel molecules, including cytokines and other biologics, that are designed to optimize their therapeutic index. These molecules are designed to localize activity within the tumor microenvironment without systemic effects, resulting in the potential to achieve enhanced anti-tumor activity. Xilio is building a pipeline of wholly owned, tumor-selective, GPS-enabled cytokine and checkpoint inhibitor product candidates, including its clinical-stage programs, XTX101, a tumor-selective anti-CTLA-4 monoclonal antibody, and XTX202, a tumor-selective IL-2, as well as its earlier pipeline, including XTX301, a tumor-selective IL-12. For more information, please visit www.xiliotx.com and follow us on Twitter (@xiliotx) and LinkedIn (Xilio Therapeutics, Inc.).